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I work as a research technician at the Biomedical Engineering and Physics department at the AMC in the Netherlands. 

 

 

Vascular Biophysics

 

 

The research of this group is devoted to the control of tone and remodeling of blood vessels, with a special interest in the role of physical factors (blood pressure and blood flow) in these processes and the biomechanics of the vascular wall. Our scientific objectives range from unraveling of basic mechanisms to understanding pathogenesis and consequences of notably hypertension, atherosclerosis, coronary artery disease and intracranial aneurysms. We use a wide variety of approaches. These include medical imaging modalities (in collaboration with Radiology), in vivo approaches such as rodent hypertension and flow restriction models, perfused arteries and arterioles of human and animal origin in organoid culture, cell-based experimental models, molecular techniques, and mathematical modeling and simulation. My group aims to combine biophysical and functional experiments with analysis of molecular parameters. Our philosophy is to perform integrative science and utilize a systems approach in order to correlate molecular mechanisms with structure and function of blood vessels and vascular networks in health and disease.

Articles 

Extravasation of Microspheres in a Rat Model of Silent Brain Infarcts

Anne-Eva van der Wijk, Nadia Lachkar, Judith de Vos, Anita E Grootemaat, Nicole N van der Wel, Peter L Hordijk, Erik Bakker, Ed Van Bavel

  • April 2019

  • Stroke

 
Blood–brain and blood–cerebrospinal fluid barrier permeability in spontaneously hypertensive rats
  • Daphne Naessens, Judith de Vos, Erik Bakker, Ed van Bavel

  • Sep 2018; Fluids and Barriers of the CNS

Nur77 protects against adverse cardiac remodelling by limiting Neuropeptide Y signalling in the sympathoadrenal-cardiac axis

Lejla Medzikovic, Cindy van Roomen, Antonius Baartscheer,Pieter B van Loenen, Judith de Vos, Erik Nicolaas Bakker, Vivian de Waard

  • May 2018

  • Cardiovascular Research

Sustained conduction of vasomotor responses in rat mesenteric arteries in a two-compartment in vitro setup

Teresa Palao, Angela van Weert, Anne Elisabeth de Leeuw, Judith de Vos, Erik Nikolaas Bakker, Ed van Bavel

  • May 2018

  • Acta Physiologica

Thrombospondin-4 mediates cardiovascular remodelling in angiotensin II-induced hypertension
  • April 2018

  • Cardiovascular Pathology

Paravascular spaces at the brain surface: Low resistance pathways for cerebrospinal fluid flow
Enhanced interstitial fluid drainage in the hippocampus of spontaneously hypertensive rats
  • Beatrice Bedussi Daphne M. P. Naessens Judith de Vos[...] Erik Nicolaas Bakker

  • Scientific Reports 7(1) · April 2017

Optimization of Vascular Casting for Three-Dimensional Fluorescence Cryo-Imaging of Collateral Vessels in the Ischemic Rat Hindlimb

Janina Schwartz ·  Monique van Lier ·  Erik N.T.P. Bakker · [...] ·  Maria Siebes

 Article · Feb 2017 · Microscopy and Microanalysis

 
 Paravascular channels, cisterns, and the subarachnoid space in the rat brain: A single compartment with preferential pathways

Beatrice Bedussi · Nicole N van der Wel · Judith de Vos · Henk van Veen · Maria Siebes · Ed VanBavel · Erik NTP Bakker 

June 2016 · Journal of Cerebral Blood Flow & Metabolism 06/2016; DOI:10.1177/0271678X16655550

Clearance from the mouse brain by convection of interstitial fluid towards the ventricular system

Beatrice Bedussi ·  Monique G. J. T. B. van Lier ·  Jonas W. Bartstra· Judith de Vos ·  Maria Siebes ·  Ed VanBavel ·  Erik N. T. P. Bakker

Fluids and Barriers of the CNS 12/2015; 12(1). DOI:10.1186/s12987-015-0019-5

 
Gene Expression and MicroRNA Expression Analysis in Small Arteries of Spontaneously Hypertensive Rats. Evidence for ER Stress

Teresa Palao ·  Karl Swärd ·  Aldo Jongejan ·  Perry D Moerland · Judith de Vos ·  Angela van Weert ·  Silvia M Arribas ·  Gergely Groma ·  Ed vanBavel ·  Erik N T P Bakker

PLoS ONE 09/2015; 10(9):e0137027. DOI:10.1371/journal.pone.0137027· 3.23 Impact Factor

 

 

Cerebral Artery Remodeling in Rodent Models of Subarachnoid Hemorrhage.

Bilge Guvenc Tuna,  Nadia Lachkar, Judith de Vos,  Erik N T P Bakker,  Ed VanBavel

Journal of Vascular Research 07/2015; 52(2):103-115. DOI:10.1159/000431366 · 2.44 Impact Factor

 

 

       Heterogeneity in Arterial Remodeling among Sublines of Spontaneously Hypertensive       Rats.

      Erik N T P Bakker, Gergely Groma, Léon J A Spijkers, Judith de Vos, Angela van Weert, Henk van Veen, Vincent Everts, Silvia M Arribas, Ed              VanBavel

      PLoS ONE 01/2014; 9(9):e107998. · 3.53 Impact Factor

 

 

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     Oxidation Monitoring by Fluorescence Spectroscopy Reveals the Age of Fingermarks

    Annemieke van Dam, Janina C. V. Schwarz, Judith de Vos, Maria Siebes, Titia Sijen, Ton G. van Leeuwen, Maurice C. G. Aalders,Saskia A. G. Lambrechts

    [Show abstract]

    Angewandte Chemie International Edition 05/2014; · 13.73 Impact Factor

     

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  • Smooth Muscle Contractile Plasticity in Rat Mesenteric Small Arteries: Sensitivity to Specific Vasoconstrictors, Distension and Inflammatory Cytokines.

    Bilge Guvenc Tuna, Marieke J C Schoorl, Erik N T P Bakker, Judith de Vos, Ed Vanbavel

    [Show abstract]

    Journal of Vascular Research 07/2013; 50(3):249-262. · 2.43 Impact Factor

     

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    Transglutaminase activity regulates atherosclerotic plaque composition at locations exposed to oscillatory shear stress.

    Hanke L Matlung, Annette E Neele, Harald C Groen, Kim van Gaalen, Bilge Guvenc Tuna, Angela van Weert, Judith de Vos,Jolanda J Wentzel, Mark Hoogenboezem, Jaap D van Buul, Ed Vanbavel, Erik N T P Bakker

    Atherosclerosis 08/2012; 224(2):355-62. · 3.71 Impact Factor

     

     

 

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    Strain-dependent susceptibility for hypertension in mice resides in the natural killer gene complex.

    Zhila Taherzadeh, Ed VanBavel, Judith de Vos, Hanke L Matlung,Gert van Montfrans, Lizzy M Brewster, Leonard Seghers, Paul H A Quax, Erik N T P Bakker

    AJP Heart and Circulatory Physiology 02/2010; 298(4):H1273-82. · 3.63 Impact Factor

     

     

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    Calcification locates to transglutaminases in advanced human atherosclerotic lesions.

    Hanke L Matlung, Harald C Groen, Judith de Vos, Theo van Walsum, Aad van der Lugt, Wiro J Niessen, Jolanda J Wentzel,Ed Vanbavel, Erik N T P Bakker

    American Journal Of Pathology 09/2009; 175(4):1374-9. · 4.52 Impact Factor

     

     

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    G0 cell cycle arrest alone is insufficient for enabling the repair of ionizing radiation-induced potentially lethal damage.

    Chris van Bree, Hans M Rodermond, Rosemarie ten Cate, Judith de Vos, Lukas J A Stalpers, Jaap Haveman, Jan Paul Medema,Nicolaas A P Franken

    Radiation Research 09/2008; 170(2):184-91. · 2.70 Impact Factor

     

     

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    Mismatch repair proficiency is not required for radioenhancement by gemcitabine.

    Chris van Bree, Hans M Rodermond, Judith de Vos, Jaap Haveman, Nicolaas A P Franken

    International Journal of Radiation OncologyBiologyPhysics 09/2005; 62(5):1504-9. · 4.52 Impact Factor

     

     

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